5184 – The Molecular Origins of Life I

Diese Vorlesung findet (auf Englisch) als Hybridveranstaltung statt.
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Zoom link:
https://us02web.zoom.us/j/84113237549?pwd=lTQzcHX5T5GqZQztAd7sVDdFsIQ1pc.1
Meeting ID: 841 1323 7549
Access code: 422339
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Die Kursmaterialen und weitere Infos sind auch unter dem folgenden Link verfügbar:
https://www.ioc.kit.edu/pianowski/99_325.php
Die Vorlesungen (7 Einheiten) werden am Donnerstags zwischen 11:30 und 13:00 Uhr durchgeführt.
Erste Vorlesung: 15. Mai 2025 (Die Folien werden kurz vor den entsprechenden Vorlesungen verfügbar)
Folgende Vorlesungen: 22.05., 05.06., 26.06., 03.07., 10.07. and 17.07.
Anfragen: pianowski@kit.edu

This lecture will be performed in the hybrid format (on-site lecture + online).
----------------------
Zoom link:
https://us02web.zoom.us/j/84113237549?pwd=lTQzcHX5T5GqZQztAd7sVDdFsIQ1pc.1
Meeting ID: 841 1323 7549
Access code: 422339
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The lecture will be held in English. The lecture slides (as PDF) as well as current information is also available under:
hhttps://www.ioc.kit.edu/pianowski/99_325.php
Lectures (7 lecture units) will take place on Thursdays 11:30-13:00 from 15. May 2025.
The lecture slides will be available for download shortly before the respective lecture.

In case of technical problems or questions, write me a message: pianowski@kit.edu

7 lecture units: 15.05., 22.05., - , 05.06., -, -, 26.06., 03.07., 10.07. and 17.07.

Following topics will be discussed:

1) Definitions of life – e.g. self-replicating chemical systems that use external energy sources to stay out of the equilibrium;
2) The origin of atoms and simple molecules - how the Universe, stars, planets, and molecules building them were formed?
3) Minimal requirements for a habitable environment – under which conditions the known forms of life can exist? Hypothetical other chemistries that could form living systems elsewhere;
4) The primordial soup – what pool of biologically relevant molecules likely existed on the prebiotic Earth: the Miller-Urey experiment, the formose reaction, prebiotic syntheses of aminoacids, sugars, nucleic acids, nucleotides, and lipids, prebiotic polymerization;
5) The origin of life – self-replicating systems, metabolism-first vs. gene-first, the “RNA world”, the origins of homochirality;
6) Formation of protocells – enhancing RNA with polypeptides, establishment of the genetic code, DNA as the enhanced information storage, metabolic networks, membranes;
7) From molecules to cells – LUCA (Last Universal Common Ancestor), information storage and function – split on different molecules, origins of the genetic code, metabolic networks and lipid membranes;
8) The history of life on Earth – timeline for LUCA, beginning of photosynthesis and aerobic metabolism, Eukaryotes, multicellular life, extremophilic organisms, habitable worlds outside Earth – current status of knowledge, space exploration programs;

Master and senior bachelor students

PD Dr. Zbigniew Pianowski

Bachelor & Master

Gestern

17. Jul 2025

Vorlesung

HS II Geb. 30.41

wöchtl.

Deutsch

All rights reserved

Zbigniew Pianowski

pianowski@kit.edu

Unbegrenzt – wenn online geschaltet

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