5184 – The Molecular Origins of Life I

Diese Vorlesung findet (auf Englisch) als Live-Stream statt.
Die interessierte Studierende: schicken Sie bitte eine E-Mail an pianowski@kit.edu
Die Kursmaterialen und weitere Infos sind unter dem folgenden Link verfügbar:
http://www.ioc.kit.edu/pianowski/99_216.php
Die Vorlesungen (7 Einheiten) werden am Dienstags und am Donnerstags zwischen 15:30 und 17:00 Uhr durchgeführt.
Erste Vorlesung: 27.April 2021 (Die Folien werden kurz vor den entsprechenden Vorlesungen verfügbar)

This lecture will be broadcasted online. If you are interested in participation, please send an E-mail to: pianowski@kit.edu
The lecture will be held in English. The lecture slides (as PDF) as well as current information is also available under:
http://www.ioc.kit.edu/pianowski/99_216.php
Lectures (7 lecture units) will take place on Tuesdays and Thursdays 15:30-17:00 from 27. Apr. 2021, (the lecture slides will be available for download shortly before the respective lecture)
To enter the lecture, follow the link:
https://us02web.zoom.us/j/85664353034?pwd=TkthdW9XNkZ6eXd6bTBsUVI4YXd6Zz09
or you can type the following parameters in Zoom software:
Meeting ID: 856 6435 3034
Passcode: 758194
If technical problems occur, write me promptly an e-mail: pianowski@kit.edu

Following topics will be discussed:

1) Definitions of life – e.g. self-replicating chemical systems that use external energy sources to stay out of the equilibrium;
2) The origin of atoms and simple molecules - how the Universe, stars, planets, and molecules building them were formed?
3) Minimal requirements for a habitable environment – under which conditions the known forms of life can exist? Hypothetical other chemistries that could form living systems elsewhere;
4) The primordial soup – what pool of biologically relevant molecules likely existed on the prebiotic Earth: the Miller-Urey experiment, the formose reaction, prebiotic syntheses of aminoacids, sugars, nucleic acids, nucleotides, and lipids, prebiotic polymerization;
5) The origin of life – self-replicating systems, metabolism-first vs. gene-first, the “RNA world”, the origins of homochirality;
6) Formation of protocells – enhancing RNA with polypeptides, establishment of the genetic code, DNA as the enhanced information storage, metabolic networks, membranes;
7) From molecules to cells – LUCA (Last Universal Common Ancestor), information storage and function – split on different molecules, origins of the genetic code, metabolic networks and lipid membranes;
8) The history of life on Earth – timeline for LUCA, beginning of photosynthesis and aerobic metabolism, Eukaryotes, multicellular life, extremophilic organisms, habitable worlds outside Earth – current status of knowledge, space exploration programs;

Dr. Zbigniew Pianowski

Organische Chemie

Bachelor & Master

1

27. Apr 2021

20. Mai 2021

Vorlesung

Wahlpflichtfach

Vorlesung Dienstags+Donnerstags 15:30-17:00 (7 Vorlesungen)

Deutsch

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6. Apr 2021, 14:15 - 31. Jul 2021, 18:35

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27. Apr 2021 - 20. Mai 2021

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